Psammomys obesus fat sand rat animal diversity web. Since the increasing prevalence of obesity is one of the major health problems of the modern era, understanding the mechanisms of orogustatory detection of dietary fat is critical for the prevention and treatment of obesity. Developmental biology of the psammomys obesus pancreas. Objective in the current study, we examined the mechanisms that regulate hepatic apolipoprotein b apobcontaining lipoprotein secretion in psammomys obesus, a good animal model for the investigation of insulin resistance and diabetes. Psammomys obesus is an animal model of the nutritionally induced type 2.
Psammomys obesus is a relevant model of nutritional diabetes since these adult animals exhibit a state of insulin resistance when fed a standard laboratory chow, hypercaloric for them as compared to their natural food. The sand rat, psammomys obesuscretzschmar, 1828, is a diurnal rodent, belonging to gerbillidae family. The sand rat has some unique attributes, which make it a valuable experimental animal. Ijms free fulltext highenergy diet and shorter light. The dietary effects of hyperglycemia increasingly result in type 2 diabetes in humans. Lewis 1891 an elementary latin dictionary, new york. This species usually lives in sandy deserts, but may also be found in rocky terrain or saline marsh areas.
Psammomys obesus wikispecies, free species directory. Abstract a study was undertaken between november 2008 and march 2010, in the focus of cutaneous leishmaniasis of central tunisia, to evaluate the role of psammomys obesus n472 and meriones shawi n167 as reservoir hosts for leishmania major infection. The desert gerbil psammomys obesus as a model for metformin. Pdf psammomys obesus, a particularly important animal model. Psammomys obesus is a diurnal gerbil that lives in north african and eastern mediterranean semidesert regions.
Cl can be diagnosed and treated in about 250 health centers around the country. Cell dysfunction in psammomys obesus, an animal with type 2 diabetes pdf. Desert sand rats psammomys obesus are indigenous to middle eastern semiarid. Impact of obesity and leptin treatment on adipocyte gene expression in psammomys obesus article pdf available in journal of endocrinology 1641. Journal of diabetes and metabolism omics international. The sand rat, psammomys obesus, develops type 2 diabetic. The gerbil, psammomys obesus sand rat, 47 is characterized by primary insulin resistance and is a welldefined model for dietaryinduced t2dm. The vascular organization of the kidney of psammomys obesus has been studied by injecting silicone rubber into the renal arterial and venous vessels and by standard histological techniques. Psammomys obesus gerbils, also known as the fat sand rat, were captured in the algerian sahara, and housed in individual cages in an animal facility university of algiers under controlled temperature and lighting conditions, with free access to food and water. The fat sand rat psammomys obesus is a terrestrial mammal from the gerbil subfamily that is. Gerbillinae, a diurnal gerbillid rodent, is herbivorous and able to thrive while consuming only the saltbush atriplex. Pdf impact of obesity and leptin treatment on adipocyte.
Reproduction and abundance of the fat sand rat psammomys. Islets from hyperglycemic animals utilized twice as much glucose as islets from normoglycemic diabetesprone or diabetesresistant controls but. The fat sand rat psammomys obesus obesus undergoes agere. Islet protection and amelioration of diabetes type 2 in. The desert gerbil psammomys obesus sand rat, a model of nutritionally induced insulin resistance and noninsulindependent diabetes mellitus, was treated after weaning with exogenous insulin implants in the normoglycaemic, normoinsulinaemic state. Intestinal and hepatic cholesterol carriers in diabetic. Spiny mice exemplify a pathway that leads to diabetes without marked insulin resistance due to low supply. Psammomys obesus sand rats exposed to neutral 12 light. Ang psammomys obesus sakop sa kahenera nga psammomys sa kabanay nga ilaga. Immunohistochemical methods allowed us to study ovarian function, the preliminary results were presented. In its native habitat, feeding mainly on the lowcalorie atriplex halimus plant, p.
Feeding psammomys a high caloric diet results in a reversible metabolic syndrome consisting of hyperglycemia, hyperinsulinemia, hypertriglyceridemia, and a moderate elevation in body weight. Psammomys obesus, a particularly important animal model for the. Psammomys obesus belongs to a family of desert gerbils and is used as a model of human t2d. Psammomys obesus, a particularly important animal model for the study of the human diabetic nephropathy. Evidence for the existence of two distinct species. Fine structure and behaviour of a pericentric inversion in the sand rat, psammomys obesus. Pdf type 2 diabetes is characterized by insulin resistance and progressive betacell failure. We investigated the effects of highenergy diet and photoperiod length on visceral and subcutaneous adipose tissue phenotype. Whereas the cortical vasculature is not principally different from that of other species, the medullary vessels show some unique features in the psammomys. Pagka karon wala pay siak nga nalista ubos niini niya. Pdf the identification of a tapeworm rodentolepis nana, formerly named hymenolepis nana infection in a research breeding colony of sand rats. The psammomys is genetically predisposed to noninsulindependent diabetes mellitus, whereas environmental and nutritional factors contribute to the expression of diabetes. Psammomys obesus, a particularly important animal model. Leishmania major infection among psammomys obesus and.
Methods and results when fed chow ad libitum, 22% maintained normoglycemia and normoinsulinemia group a, 33%. Histological sections of liver from animals on both diets were examined for key features of nonalcoholic steatohepatitis. While every effort has been made to provide the most reliable and uptodate information available, ultimate legal requirements with respect to species are contained in. Spiny mice exemplify a pathway that leads to diabetes without marked insulin resistance due to low supply of insulin on abundant. All structured data from the file and property namespaces is available under the creative commons cc0 license. The israeli sand rat, psammomys obesus, a desert gerbil, uses a predominantly vegetarian diet in its natural habitat. Albino rats matched for weight and age served as high energy diet adjusted reference animals. Early onset of disk degeneration and spondylosis in sand. The fat sand rat, psammomys obesus lives in the arid zones of north africa and eastern mediterranean region. These taxa have been the subject of taxonomic controversy for some time, due to variability in the classical morphological characters used for taxonomic recognition. Camille harris, in manual of exotic pet practice, 2009. Medical care is provided for free, which includes diagnosis and treatment of leishmaniasis. The vascular organization of the kidney of psammomys obesus.
The fat sand rat psammomys obesus is the main reservoir host of cutaneous leishmaniasis in north africa and western asia. Peter greaves mbchb frcpath, in histopathology of preclinical toxicity studies fourth edition, 2012. Pdf tapeworm identification in the fat sand rat psammomys. Amyloid is deposited in islets of langerhans in amyloidprone laboratory species and is found in pancreatic islets in mice with advanced amyloidosis. As a result of this strategy, fat sand rats do not need to drink free standing. Meanwhile, the body weight and blood glucose of the. Both insulin resistance and diabetes in psammomys obesus.
Adw doesnt cover all species in the world, nor does it include all the latest scientific information about organisms we describe. Sand rats have been used for the study of renal function, and since they may develop diabetes if kept on a laboratory diet without a supplement of salt bush, they have been used for investigation of diabetesrelated disorders as well. Una ning gihulagway ni philipp jakob cretzschmar ni adtong 1828. Mitochondrial dysfunction is considered to be a pivotal component of insulin resistance and associated metabolic diseases. Pdf the psammomys obesus lives in natural desert habitat on low energy le diet. After being examined by a veterinarian to ensure that the animals were free of diseases, p. The psammomys obesus lives in natural desert habitat on low energy le diet, however when maintained in laboratory conditions with high. Rapid development of nonalcoholic steatohepatitis in.
Itis taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties. Histological and immunohistological aspects of the ovarian. Mammal species of the world a taxonomic and geographic reference. The sand rat is a desert animal which feeds mainly on salt bush, a shrub with a high salt content in its leaves. Files are available under licenses specified on their description page. Hepatic mitochondrial alterations and increased oxidative. Experiments were carried out in the small intestine and liver of psammomys obesus, a model of nutritionally. However, it is not a legal authority for statutory or regulatory purposes. Energy requirements of fat sand rats psammomys obesus and their. Islets from hyperglycemic animals utilized twice as much glucose as islets from normoglycemic diabetesprone or diabetesresistant controls but exhibited similar rates of glucose oxidation. Fine structure and behaviour of a pericentric inversion in the sand.
The expression levels of key genes involved in hepatic lipid. Read changing pattern of prevalence of insulin resistance in psammomys obesus, a model of nutritionally induced type 2 diabetes, metabolism on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. We examined the major signaling pathways for insulin release in p. In order to understand better the transmission of this disease to humans, a longitudinal study of a population of the rodent was carried out in tunisia.
Role of insulin and the igf system in renal hypertrophy in. Psammomys obesus diabetes and pregnancy my fertility guide. Though we edit our accounts for accuracy, we cannot guarantee all information in those accounts. Two species, the spiny mice acomys cahirinus and the desert gerbil psammomys obesus, which have different metabolic responses to such effects, are discussed. The disruption of circadian rhythms contributes to t2dm development. This page was last edited on 6 december 2014, at 05. The sand rat psammomys obesus, a member of the gerbil subfamily, serves as a model for nutritionally induced type 2 diabetes characterized by primary insulin resistance. Pdf psammomys obesus, a particularly important animal.
Fat sand rats are terrestrial mammals that are most often found in sandy deserts, but can be found in. It has developed a high metabolic efficiency characteristic of a thrifty metabolism. Read evidence for the existence of two distinct species. Giklaseklase sa iucn ang espesye sa kinaminosang kalabotan. The sand rat psammomys obesus as an experimental animal in. The fat sand rat psammomys obesus is a terrestrial mammal from the gerbil subfamily that is mostly found in north africa and the middle east, ranging from mauritania to the arabian peninsula. Psammomys obesus often referred to as the sand rat is prone to develop obesity, hyperglycemia and hyperinsulinemia when fed a high energy he diet 11. Psammomys, or the sand rat, is a rodent belonging to the subfamily gerbillinae. Psammomys obesus and psammomys vexillaris within the sand rats rodentia, gerbillinae, reservoirs of cutaneous leishmaniasis in tunisia, infection, genetics and evolution on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your. We have conducted the present study on psammomys obesus, the rodent desert gerbil which is a unique polygenic natural animal model of obesity. Orogustatory perception of dietary lipids and calcium. The absence of pdx1like immunoreactivity remains a mystery and inspired us to further study how the pancreas develops in these animals compared with mice and rats. Psammomys obesus synonyms, psammomys obesus pronunciation, psammomys obesus translation, english dictionary definition of psammomys obesus. Psammomys obesus is a model of type 2 diabetes that displays resistance to insulin and deranged.
Pdf caracterisation des gonades du rat des sables, psammomys. Trypanosomatidae infestation of psammomys obesus cretzschmar rodentiagerbillidae. The sand rat, psammomys obesus, develops type 2 diabetic retinopathy similar to humans. Insulin resistance in the niddm model psammomys obesus in. Free fulltext pdf articles from hundreds of disciplines, all in one place role of insulin and the igf system in renal hypertrophy in diabetic psammomys obesus sand rat pdf. Free fulltext pdf articles from hundreds of disciplines, all in one place ipf1pdx1 deficiency and. A major impediment to establishing new treatments for nonalcoholic steatohepatitis is the. The occurrence of increased plasma insulin levels and of hyperglycem.
We have evaluated and correlated the histopathology, metabolic and functional renal alterations occurring in the diabetic psammomys. Psam momys obesus, a model of type 2 diabetes, since cbd inhibits the production of il1b, tnf. This page was last edited on 14 september 2017, at 23. Psammomys obesus often referred to as the sand rat. The animal diversity web is an educational resource written largely by and for college students. Psammomys obesus, the fat sand rat, is found in north africa, ranging from mauritania to egypt and sudan, and east across the arabian peninsula.