Long term treatment with foscarnet is contraindicated in patients with a. It binds reversibly near the pyrophosphatebinding site of dna polymerase or reverse transcriptase without requiring further modification 1. J1455 hcpcs code for injection, foscarnet sodium, per mg. Solucortef sterile powder is available in several packages for intravenous or intramuscular administration. Foscarnet phosphonomethanoic acid, known by its brand name foscavir, is an antiviral medication which is primarily used to treat viral infections involving the herpesviridae family.
Foscarnet fda prescribing information, side effects and uses. Pdf penetration of foscarnet into cerebrospinal fluid of. Foscarnet trisodium phosphonoformate is a pyrophosphate analog. Foscavir injection, phosphonoformic acid foscarnet dosing.
Foscavir 24 mgml solution for infusion summary of product. Foscarnet sodium definition of foscarnet sodium by the free. Ask your health care provider about possible side effects from foscarnet sodium. Feb 21, 2019 foscarnet trisodium hexahydrate 24 mgml. Penetration of foscarnet into cerebrospinal fluid of aids. Foscarnet, phosphonoformic acid 8, is a potent and broadspectrum antiherpes agent ic 50 0. Ten percent to 28% of the cumulative dose may have been deposited in bone 2 days after.
The medicine enters the body through a catheter placed into the vein. Foscarnet is an antiviral medicine that prevents certain viruses from multiplying in your body. Foscarnet is used to treat cytomegalovirus cmv retinitis in people with aids. Renal clearance accounted for most of the plasma clearance, the difference probably reflecting the passage of foscarnet into bone. Combination antiviral therapy for ganciclovirresistant. List of drug master files dmf of foscarnet active pharmaceutical ingredient api submitted to the u. Select antiviral regimen for initial treatment of cmv retinitis in hivinfected.
Foscavir is also indicated for the treatment of mucocutaneous herpes simplex virus. Foscarnet is injected into a vein through an iv using an infusion pump. Fulldose foscarnet therapy usually administered intravenously at a minimum dosage of 60. Foscavir fda prescribing information, side effects and uses.
When inserted into a dna strand by viral dna polymerase. Jan 10, 2019 foscarnet sodium may affect the way other medicines or products work, and other medicines or products may affect how foscarnet sodium works. Animal studies have shown that foscarnet distributes into breast milk at concentrations that are three times greater than maternal plasma concentrations. No information is available on levels of foscarnet which may appear in human breast.
Foscarnet is usually given for hsv after other antiviral medications have. Foscarnet is also used to treat herpes simplex virus hsv in people with a weak immune system. Foscarnet definition of foscarnet by the free dictionary. To update dosage and administration with information regarding treatment of. Due to the potential for serious toxicities in a nursing infants, breastfeeding should be avoided during foscarnet therapy until further clarification of the risk has been made. Must not exceed recommended foscarnet dosage and recommended frequency. Foscarnet definition is a hydrated sodium salt na3co5p6h2o that is administered intravenously to individuals infected with hiv to treat retinitis caused by a cytomegalovirus. Mar, 2017 foscarnet is injected into a vein through an iv using an infusion pump. This medication is not a cure for cmv or hsv diseases. After binding, the drug blocks the cleavage of the pyrophosphate moiety from deoxynucleotide triphosphates, in turn halting dna chain. Jul 22, 2019 foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with a molecular formula of na 3 co 5 p6 h 2 o and a molecular weight of 300. The length of your treatment depends on how you respond to the medication. Package contains 25 vials of ndc 0069600102 ndc 0069600125 both sizes of vials contain tromethamine, usp tris, hydrochloric acid, nf, or sodium hydroxide, nf, and water for injection, usp.
Prehydrate with 750 ml ns or d5w before first infusion to decrease risk for nephrotoxicity. Concentrations in plasma and csf at the end of foscarnet infusion or 1, 3, 5, 6, and 12 h after infusion were determined by highperformance liquid chromatography. Dec 01, 2019 foscavir is the brand name for foscarnet sodium. Definition of foscarnet from the collins english dictionary. Ask your health care provider if there are interactions between foscarnet sodium and the other medicines you take. Foscarnet is the conjugate base of a chemical compound with the formula ho 2 cpo 3 h 2. Foscarnet phosphonomethanoic acid, known by its brand name foscavir, is an antiviral. Foscarnet is used for the treatment of invasive cmv disease among patients with suspected or documented ganciclovirresistant cmv. Foscarnet side effects, dosage, interactions drugs.
Foscavir foscarnet sodium injection side effects, images. Solucortef sterile powder is an antiinflammatory glucocorticoid, which contains hydrocortisone sodium succinate as the active ingredient. Nephrotoxicity is usually reversible and can be reduced by dosage. Recently, however, clinical cmv isolates that are resistant to ganciclovir in vitro have. For intravenous infusion foscavir, give intermittently in glucose 5% or sodium chloride 0. This phosphonic acid derivative marketed by clinigen as foscarnet sodium under the. This medication is given by injection into a vein by a health care professional in a hospital or clinic setting. M for hsv1, hsv2, hcmv, and ebv and is used in the clinic for the treatment of hcmv infection.
Foscarnet sodium is a white, crystalline powder containing 6 equivalents of water of hydration with an empirical formula of na 3 co 5 p6 h 2 o and a molecur weight of 300. Foscarnet is a synthetic organic analog of inorganic pyrophosphate with activity against several types of viruses, but primarily used for the treatment of cytomegalovirus retinitis. This site complies with the honcode standard for trustworthy health information. The disposition of foscarnet could be explained by a triexponential equation t12 lambda 1, 0. Foscarnet doses are based on renal function according to the adjusted cockroftgault equation. Foscarnet selectively blocks the pyrophosphate binding site of virusspecific dna polymerases at concentrations that do not affect cellular dna polymerases. Longterm intravitreal ganciclovir therapy for cytomegalovirus retinopathy. Nov 09, 2018 foscarnet is injected into a vein through an iv using an infusion pump. View detailed import data, price, monthly trends, major importing countries, major ports of foscavir. Foscarnet definition of foscarnet by merriamwebster. Careful attention to dosing is required given the doserelated toxicities of foscarnet. Foscarnet sodium definition of foscarnet sodium by medical. The diffusion of foscarnet into cerebrospinal fluid csf was studied in 27 patients with aids. Romain vial, christine zandotti, sophie alain, alexandre decourt, noemie jourdechiche, raj purgus, charleric bornet, laurent daniel, valerie moal, tristan legris 2017, brincidofovir use after foscarnet crystal nephropathy in a kidney transplant recipient with multiresistant cytomegalovirus infection, case reports in transplantation.
Ganciclovir, foscarnet, and cidofovir are antiviral drugs approved for use against cytomegalovirus cmv in adults by the us food and drug administration. As of 20, this field contains the consumer friendly descriptions for the ama cpt codes. The chemical name of foscarnet sodium is phosphonoformic acid, trisodium salt. Injection, foscarnet sodium, per mg drugs administered other than oral method, chemotherapy drugs j1455 is a valid 2020 hcpcs code for injection, foscarnet sodium, per mg or just foscarnet sodium injection for short, used in medical care. Foscarnet sodium is a congener of phosphonoacetic acid, and they are both the analogues of pyrophosphates. Foscarnet indications, dosage, side effects and precautions. This medication is also used to treat herpes infections hsv that do not respond to treatment with acyclovir acyclovirresistant. You may receive foscarnet injection in a hospital or you may administer the medication at home. Foscarnet injection comes as a liquid to be intravenously into a vein. This issue, all clinical infectious diseases, all idsa journals, all journals. Foscavir foscarnet sodium dose, indications, adverse. Pdf pharmacokinetics and absorption of foscarnet after.
Foscarnet foscavir generic is an antiviral medication, prescribed for cytomegalovirus cmv retinitis in patients with acquired immunodeficiency syndrome aids and resistant herpes simplex virus. Foscarnet definition of foscarnet by medical dictionary. It is usually infused slowly over 1 to 2 hours every 8 or 12 hours. Foscarnet definition and meaning collins english dictionary. Foscarnet sodium has the potential to chelate divalent metal ions, such as calcium and magnesium, to form stable coordination compounds. Foscarnetfoscavir generic is an antiviral medication, prescribed for cytomegalovirus cmv retinitis in patients with acquired immunodeficiency syndrome aids and resistant herpes simplex virus.
Continued ganciclovir valganciclovir foscarnet cidofovir hexadecyloxypropyl cidofovir cmx001. Foscavir is indicated for induction and maintenance therapy of cytomegalovirus cmv retinitis in patients with aids. Foscarnet sodium injection foscavir side effects, medical. Foscarnet sodium may also be associated with a doserelated decrease in ionized serum calcium which may not be reflected in total serum calcium. Find patient medical information for foscarnet bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Patients must be on longterm maintenance regimens with iv foscarnet to prevent the. Iv induction 60 mgkg infused over 1 h q8h for 23 wk. Foscarnet is sometimes combined with another antiviral drug, ganciclovir, when the cmv infection does not respond to either drug used alone for treatment.
Unlike interferon that exerts only short term effects,16 foscarnet sodium, which is a totally synthesized small molecule compound, functions at the pyrophosphate binding site of viral dna polymerase. Solucortef hydrocortisone sodium succinate for injection. Foscarnet sodium has been associated with changes in serum electrolytes including hypocalcemia, hypophosphatemia, hyperphosphatemia, hypomagnesemia, and hypokalemia. Due to sodium content of foscarnet 240 micromoles 5. A healthcare provider will show you how to use an infusion pump. It is classified as a pyrophosphate analog dna polymerase inhibitor. Foscarnet was administered intravenously at various dosages at 12h intervals. Longterm foscarnet therapy remodels thymidine analogue mutations and.